Retina International's Scientific Newsletter

	Retina International's Scientific Newsletter
Editor's Notes from literature on Na-Ca-K-Exchanger (NCKX)

Recent update from: 19.12.1999

NCKX

Notes

64,3% identity to bovine rod NCKX

Species: Homo sapiens

See also:

Chromosomal localisation	in man:
	in mouse:

Gene Data

Exons:

Primers:

Protein Data

Aminoacids: 1081 AA

Molecularweight	on SDS-PAGE:
	calculated:

Reference: (2)

NCKX, rod

Notes

Heavily glycosylated
3 large hydrophobic domains
First 65 AA are necessary for membrane association with microsomal membranes and increase efficiacy for membrane targeting
Signal sequence is not cleaved in vivo and vitro
Signal is necessary to translocate the great N-terminus
3 hydrophobic domains
Transport ratio 4 Na⁺ out : 1 Ca²⁺ and 1 K⁺ in

Species: Bos taurus

See also:

Chromosomal localisation	in man:
	in mouse:

Gene Data

Exons:

Primers:

Protein Data

Aminoacids: 1190 AA

Molecularweight	on SDS-PAGE: 220 kDa
	calculated:

Reference: (1)

References:

1. Friedlander, M. and McKiernan, C.J. The N-Terminus of the Na+/Ca2+-K+ Exchanger Functions As A Non-Cleaved Signal Sequence. 1998; Invest.Ophthalmol.Vis.Sci. 39: S678
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2. Tucker, J.E., Winkfein, R.J., Cooper, C.B., and Schnetkamp, P.P. cDNA cloning of the human retinal rod Na-Ca + K exchanger: comparison with a revised bovine sequence. 1998; Invest.Ophthalmol.Vis.Sci. 39: 435 - 440.
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Contact the editor: irpamp@irpa.org	This site is maintained and edited by Dr. rer. medic. Markus Preising, Dipl.Biol. Molecular Genetics Laboratory Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics University of Regensburg Head: Prof. Dr. med. Birgit Lorenz