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The Protein Pages

Tissue Inhibitor of
Metalloproteases 3
(TIMP3)

To see compiled data on further species click on the topics.
To see the reference for the human data click on the data

Editor's Notes from the Literature

Recent update from: 08.07.00


Description

The Tissue Inhibitor of Metalloproteases 3 (TIMP3) is a regulatory protein controlling tissue degradation in the eye by inhibiting proteases that breakdown proteins from ingested cells and cell parts (outer segments) in RPE.

GENE DATA

Exons: 5

Markers / RFLPs:

Transcripts:

Regulatory elements:


Primers:

Chromosome 22 with TIMP3 locus
Assignment: 22q12-13.2 Involvement in Retinal Degenerations:

click here to see a compilation of

CLICK

several Mutations found to underlie

Sorsby's Fundus Dystrophy

PROTEIN DATA

Subunits: 1 Amino acids: 188 AA
Modifications:


Mr/ Weight:


Cofactors:


Motifs:



PROTEIN DATA

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Protein Subtype Locus Species EC-No. Swissprot PIR Prosite
Tissue Inhibitor of Metalloproteases TIMP1 TIMP Bos taurus EC- P20414 A35685 B34468 B29712 A34833 I46979 PS00288
Tissue Inhibitor of Metalloproteases TIMP2 TIMP Bos taurus EC- P16368 A35996 A34468 A25322 S28151 B35996 A34464 A34415 S21303 S20319 S17165 PS00288
Tissue Inhibitor of Metalloproteases TIMP3 TIMP Bos taurus EC- P79121

Tissue Inhibitor of Metalloproteases TIMP2 TIMP Cricetus cricetus EC-
S38624
Tissue Inhibitor of Metalloproteases TIMP3 TIMP Gallus gallus EC- P26653 A43429 A39043
Tissue Inhibitor of Metalloproteases TIMP1 TIMP Homo sapiens EC- P01033 Q14252 A20595 A48417 A35826 A93372 A23534 S20318 A93363 A01269 PS00288
Tissue Inhibitor of Metalloproteases TIMP2 TIMP Homo sapiens EC- P16035 A37128 I53729 A34464 S20319 A34415 B35996 S21303 S17165 PS00288
Tissue Inhibitor of Metalloproteases TIMP3 TIMP Homo sapiens EC- P35625 S45317 S59515 S53870 I38023 A49614 C56997 I53025
Tissue Inhibitor of Metalloproteases TIMP1 TIMP Mus musculus EC- P12032 P20064 A26106 A26917 A26633 A05276 PS00288
Tissue Inhibitor of Metalloproteases TIMP2 TIMP Mus musculus EC- P25785 JH0683 JC1234 S18428 S15987 S26189
Tissue Inhibitor of Metalloproteases TIMP3 TIMP Mus musculus EC- P39876 A53532 S43053 A56937 B56937 I53108 S43052
Tissue Inhibitor of Metalloproteases TIMP1 TIMP Oryctolagus cuniculus EC- P20614 A33350 A30864 PS00288
Tissue Inhibitor of Metalloproteases TIMP1 TIMP Ovis aries EC- P50122 I46964
Tissue Inhibitor of Metalloproteases TIMP1 TIMP Rattus norvegicus EC- P30120 P70533 JC2557 B39120 S20326
Tissue Inhibitor of Metalloproteases TIMP2 TIMP Rattus norvegicus EC- P30121 S45683 I53415 S20325 S60160
Tissue Inhibitor of Metalloproteases TIMP3 TIMP Rattus norvegicus EC- P48032 JC4630
Tissue Inhibitor of Metalloproteases TIMP1 TIMP Sus scrofa EC- P35624


GENE DATA

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Gene Subtype Locus Species Genbank Unigene Medline
Tissue Inhibitor of Metalloproteases TIMP1 TIMP Bos taurus S70841 M60073
94257757 90365711
Tissue Inhibitor of Metalloproteases TIMP2 TIMP Bos taurus M32303
90207285
Tissue Inhibitor of Metalloproteases TIMP3 TIMP Bos taurus U77588
97138091
Tissue Inhibitor of Metalloproteases TIMP1 TIMP Equus caballus U95039

Tissue Inhibitor of Metalloproteases TIMP2 TIMP Gallus gallus AF004664

Tissue Inhibitor of Metalloproteases TIMP3 TIMP Gallus gallus M94531 AF004664 M60412 M60413
92381050
Tissue Inhibitor of Metalloproteases TIMP1 TIMP Homo sapiens S68252 X03124 M12670 X02596 M59906 D11139 L47361 A10416 D26513 Y09720 L47357 M24603 X52828 X52829 X02598 NM_003254 Hs.5831 94123576 86040463 86205964 85240564 91025550 97307877
Tissue Inhibitor of Metalloproteases TIMP2 TIMP Homo sapiens S68860 J05593 U44381 U44382 U44383 U44384 U44385 X54533 S48568 M32304 NM_003255 AH006644 Hs.6441 90338014 94156197 96411768
Tissue Inhibitor of Metalloproteases TIMP3 TIMP Homo sapiens U02571 AF001361 U14394 U67195 S78453 S79779 X76227 U38952 S78453 D45917 U38953 U38954 U38955 U33110 U33111 U33112 U33113 U33114 U14394 Z98256 G06760 AL023282 L15078 NM_000362 AH006629 Hs.245188 95201800 94215920 96091365 94228524 96235152 94245184 95290091 96033052 96042499
Tissue Inhibitor of Metalloproteases TIMP4 TIMP Homo sapiens NM_003256 AH006411 U76456 Hs.190787
Tissue Inhibitor of Metalloproteases
TIMP Mus musculus M28311 M28312 X04684 M17243 X69413 M21162 NM_011593 AH004952 M28308 M28309 M28310 M28311 Mm.8245
Tissue Inhibitor of Metalloproteases TIMP1 TIMP Mus musculus M28308 M28309 M28310 M28311 M28312 X04684 M17243 X69413
93042007 87066763 87218524
Tissue Inhibitor of Metalloproteases TIMP2 TIMP Mus musculus X62622 M93954 M21162 M65031 S37984 M82858 NM_011594 Mm.19191 92290292 92347695 89096910
Tissue Inhibitor of Metalloproteases TIMP3 TIMP Mus musculus U19462 L19622 L15078 M28308 M28309 M28310 M28311 Z30970 U26433 U26437 U26434 U26435 U26436 Z31358 L27424 NM_011595 AH003325 Mm.4871 94163596 95301511 94179361 95370262 95036582
Tissue Inhibitor of Metalloproteases TIMP1 TIMP Oryctolagus cuniculus J04712
89214135
Tissue Inhibitor of Metalloproteases TIMP1 TIMP Ovis aries S67450
94102210
Tissue Inhibitor of Metalloproteases TIMP1 TIMP Rattus norvegicus U06179 L31883 L29512 U16022
95011636 96317624
Tissue Inhibitor of Metalloproteases TIMP2 TIMP Rattus norvegicus S72594 S82718 U14526 L31884
96384329 94263207
Tissue Inhibitor of Metalloproteases TIMP3 TIMP Rattus norvegicus U27201 NM_012886 Rn.40532
Tissue Inhibitor of Metalloproteases TIMP1 TIMP Sus scrofa S67450 S96211
92201478


GENE LOCUS DATA

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Gene Subtype Locus Species Genome Database Mouse Genome Database OMIM Locus Link
Tissue Inhibitor of Metalloproteases TIMP1 TIMP Homo sapiens 119615
305370
Tissue Inhibitor of Metalloproteases TIMP1 TIMP Homo sapiens


7076
Tissue Inhibitor of Metalloproteases TIMP2 TIMP Homo sapiens 132612
188825 7077
Tissue Inhibitor of Metalloproteases TIMP3 TIMP Homo sapiens 138175
188826 7078
Tissue Inhibitor of Metalloproteases TIMP4 TIMP Homo sapiens 5584685
601915 7079
Tissue Inhibitor of Metalloproteases
TIMP Mus musculus


21857
Tissue Inhibitor of Metalloproteases TIMP2 TIMP Mus musculus


21858
Tissue Inhibitor of Metalloproteases TIMP3 TIMP Mus musculus


21859
Tissue Inhibitor of Metalloproteases TIMP4 TIMP Mus musculus


21860
Tissue Inhibitor of Metalloproteases TIMP2 TIMP Rattus norvegicus


29543
Tissue Inhibitor of Metalloproteases TIMP3 TIMP Rattus norvegicus


25358


References:
1. Felbor,U., Suvanto,E.A., Forsius,H.R., Eriksson,A.W., and Weber,B.H. Autosomal recessive Sorsby fundus dystrophy revisited: molecular evidence for dominant inheritance. 1997; Am.J.Hum.Genet. 60: 57-62.
Goto Top Link to PudMed
2. Silbiger,S.M., Jacobsen,V.L., Cupples,R.L., and Koski,R.A. Cloning of cDNAs encoding human TIMP-3, a novel member of the tissue inhibitor of metalloproteinase family. 1994; Gene. 141: 293-297.
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3. Weber,B.H.F., Vogt,G., Wolz,W., Ives,E.J., and Ewing,C.C. Sorsby's fundus dystrophy is genetically linked to chromosome 22q13-qter. 1994; Nat.Genet. 7: 158-161.
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Contact the editor: irpamp@irpa.org
This site is maintained and edited by
Dr. rer. medic. Markus Preising, Dipl.Biol.
Molecular Genetics Laboratory
Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics
University of Regensburg
Head: Prof. Dr. med. Birgit Lorenz