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The Protein Pages

Rhodopsinkinase
(RK, RHOK, GRK1)

To see compiled data on further species click on the topics.
To see the reference for the human data click on the data

Editor's Notes from the Literature

Recent update from: 08.07.00


Description

Rhodopsin kinase (RHOK) is a serine/threonine kinase that phosphorylates RHO at bright light to start the regeneration of the light activated photoreceptor . (2).

GENE DATA

Exons: 7

Markers / RFLPs:

Transcripts: 2,8 and 7 kb

Regulatory elements:

Primers: Complete

Chromosome 13 with RK locus
Assignment: 13q34 Involvement in Retinal Degenerations:

click here to see a compilation of

CLICK

several Mutations found to underlie

Oguchi Disease
ADRP
ARRP

PROTEIN DATA

Subunits: 1 Amino acids: 564 AA
Modifications: Mr/ Weight: 63,5 kDa
Cofactors: Motifs:

PROTEIN DATA

Click on entry to see database record online
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Protein Subtype Locus Species EC-No. Swissprot PIR Prosite
Rhodopsin Kinase
RHOK Bos taurus EC 2.7.1.125 P28327 A41365 PS00107 PS00108 PS50011
Rhodopsin Kinase
RHOK Homo sapiens EC 2.7.1.125 Q15835
PS00107 PS00108 PS50011
Rhodopsin Kinase
RHOK Rattus norvegicus EC 2.7.1.125 Q63651
PS00107 PS00108 PS50011


GENE DATA

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Gene Subtype Locus Species Genbank Unigene Medline
Rhodopsin Kinase
RHOK Bos taurus M73836
96216396 92020922
Rhodopsin Kinase
RHOK Homo sapiens U63973 NM_002929 Hs.103501
Rhodopsin Kinase
RHOK Mus musculus NM_011881 AF085240 Mm.89980
Rhodopsin Kinase
RHOK Rattus norvegicus U63971


GENE LOCUS DATA

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Gene Subtype Locus Species Genome Database Mouse Genome Database OMIM Locus Link
Rhodopsin Kinase
RHOK Homo sapiens 371598
180381 258100 6011
Rhodopsin Kinase
RHOK Mus musculus


24013


References:
1. Chen,C.K., Inglese,J., Lefkowitz,R.J., and Hurley,J.B. Ca(2+)-dependent interaction of recoverin with rhodopsin kinase. 1995; J.Biol.Chem. 270: 18060-18066.
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2. Khani,S.C., Abitbol,M., Yamamoto,S., Maravic Magovcevic,I., and Dryja,T.P. Characterization and chromosomal localization of the gene for human rhodopsin kinase. 1996; Genomics. 35: 571-576.
Goto Top Link to PudMed
3. Khani,S.C., Nielsen,L., and Vogt,T.M. Biochemical evidence for pathogenicity of rhodopsin kinase mutations correlated with the oguchi form of congenital stationary night blindness. 1998; Proc.Natl.Acad.Sci.U.S.A. 95: 2824-2827.
Goto Top Link to PudMed
4. Khani,S.C., Young,J.E., Vogt,T.M., and Gross,K. Funktional characterization of the rhodopsin kinase (RK) gene promoter. 2000; Invest.Ophthalm.Vis.Sci. 41: S390
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5. Palczewski,K. and Benovic,J.L. G-protein-coupled receptor kinases. 1991; Trends.Biochem.Sci. 16: 387-391.
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6. Premont,R.T., Koch,W.J., Inglese,J., and Lefkowitz,R.J. Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. 1994; J.Biol.Chem. 269: 6832-6841.
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7. Yamamoto,S., Sippel,K.C., Berson,E.L., and Dryja,T.P. Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness. 1997; Nat.Genet. 15: 175-178.
Goto Top Link to PudMed

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Contact the editor: irpamp@irpa.org
This site is maintained and edited by
Dr. rer. medic. Markus Preising, Dipl.Biol.
Molecular Genetics Laboratory
Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics
University of Regensburg
Head: Prof. Dr. med. Birgit Lorenz