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Editor's Notes

from literature on

RPE-retinal G-protein-coupled Receptor (RGR)

Editor's Notes

Recent update from: 03.01.2000


RGR, Notes

  • Member of heptahelical receptor family
  • Resembles most closely the family of photoreceptors
  • In analogy to RHO a Lys is conserved in the seventh hydrophobic segment as a potential chromophor binding site
  • Localised in RPE and Müller cells
Species: Homo sapiens
See also:
Chromosomal localisation in man:

in mouse:
Gene Data
mRNA: 1.5 kb
Exons:
Primers:
Protein Data
Amino acids: 291
Molecular weight on SDS-PAGE: 32 kDa

calculated: 31959
Reference: (1)


RGR, Notes

  • Markers: D10S1786-RGR-D10S1658-D10S1744
  • 2 families segregating 2 disease causing mutations
  • Light percieved by RGR converts atRal to 11cRAl (!)
  • Localized in RPE and Müller cells
Species: Homo sapiens
See also:
Chromosomal localisation in man: 10q23

in mouse:
Gene Data

:

Exons:
Primers:
Protein Data
Amino acids:
Molecular weight on SDS-PAGE:

calculated:
Reference: (2)


References:

1. Jiang, M., Pandey, S., and Fong, H.K. An opsin homologue in the retina and pigment epithelium. 1993; Invest.Ophthalmol.Vis.Sci. 34: 3669 - 3678.
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2. Morimura, H., Saindelle-Ribeaudeau, F., Berson, E.L., and Dryja, T.P. Mutations in RGR, encoding a light-sensitive opsin homologue, in patients with retinitis pigmentosa. 1999; Nat.Genet. 23: 393 - 394.
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Dr. rer. medic. Markus Preising, Dipl.Biol.
Molecular Genetics Laboratory
Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics
University of Regensburg
Head: Prof. Dr. med. Birgit Lorenz