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Editor's Notes

from literature on

Retinyl Ester Hydrolase (REH)

Editor's Notes

Recent update from: 19.12.1999


REH Notes

  • Catalyzes hydrolysis of stored Ry, preferred 11cis-palmitate
  • Localized in RPE membranes
  • Distinct from cholesterol-hydrolase activity and atREH
  • 11cRy comprise 75% of total Ry pool of RPE
  • Distribution of Ry: 99% of vitamin A in the eye -> 75% 11cis-ester -> 57% palmitate, 25% stearate, 10% oleate, 1.1% myristate, 0.6% linoleate
  • Preferrence: palmitate >oleate = linoleate >myristat = stearate
  • 9/13-cis and all-trans are inhibited substrate
Species:
See also:
Chromosomal localisation in man:

in mouse:
Gene Data

Exons:
Primers:
Protein Data
Aminoacids:
Molecularweight on SDS-PAGE:

calculated:
Reference: (1)


REH Notes

Species: Bos taurus
See also:
Chromosomal localisation in man:

in mouse:
Gene Data

Exons:
Primers:
Protein Data
Aminoacids:
Molecularweight on SDS-PAGE:

calculated:
Reference: (2)


References:

1. Mata, J.R., Mata, N.L., and Tsin, A.T. Substrate specificity of retinyl ester hydrolase activity in retinal pigment epithelium. 1998; J.Lipid Res. 39: 604 - 612.
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2. Sierra, D.A., Tsin, A.T.C., Mata, N.L., and Villazana, E.T. Subcellular Distribution of 11-cis LRAT, 11-cis RD, and 11-cis REH in Bovine Pigment Epithelium. 1998; Invest.Ophthalmol.Vis.Sci. 39: S39
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Dr. rer. medic. Markus Preising, Dipl.Biol.
Molecular Genetics Laboratory
Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics
University of Regensburg
Head: Prof. Dr. med. Birgit Lorenz