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Scientific Newsletter


Retinal Proteins
Not Involved In Retinal Disorders

Recent update from: 06.02.2000


Propteins of the Recovery and Supply of the Chromophore.
This page summarizes data on human proteins involved in the recovery and supply of the chromophore.
If you click on a protein on the right, you will find listings of data on this protein and further pages providing information from internet databases on that protein can be accessed. These data include information on animal proteins too.

Cellular Retinol-binding Protein (CRBP1, CRBP2 = RBP1, RBP2)
Human Data
Source data from literature
on this protein can be obtained here.
Editor's Notes
Subunit Subunits Aminoacids Modifications
  1. CRBP1
  2. CRBP2
  1. 1
  2. 1
  1. 134 AA


Mr / Weight Cofactors / Substrates
  1. CRBP1
  2. CRBP2
  1. 15,7 kDa


Exons Transcripts Regulatory Elements
  1. CRBP1
  2. CRBP2
  1. 4



Markers / RFLPs Primers Assignment
  1. CRBP1
  2. CRBP2


  1. 3q12-22
  2. 3p11-qter


PROTEIN DATA

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Protein Subtype Locus Species EC-No. Swissprot PIR Prosite
Cellular Retinol-binding Protein
RBP1, CRBP1 Bos taurus EC- P02694 I46955 A03148 A32704 S00400 B40902 A92528 A91295 A03151 PS00214
Cellular Retinol-binding Protein
RBP2, CRBP2 Gallus gallus EC-
A61113 A26969
Cellular Retinol-binding Protein type 1 RBP1, CRBP1 Homo sapiens EC- P09455 P02753 S00399 A03223 S06278 A27786 PS0021 PS00213
Cellular Retinol-binding Protein type 2 RBP2, CRBP2 Homo sapiens EC- P09455 A40902 S00399 S02300 A32704 S00400 B40902 A92528 A91295 A03151
Cellular Retinol-binding Protein type 1 RBP1, CRBP1 Mus musculus EC- Q00915 S16355 PS00214
Cellular Retinol-binding Protein type 2 RBP2, CRBP2 Mus musculus EC- Q08652 S34717 I48311 PS00214
Cellular Retinol-binding Protein type 1 RBP1, CRBP1 Rattus norvegicus EC- P02696 A92527 A92455 A29570 A28016 A03149 PS00214
Cellular Retinol-binding Protein type 2 RBP2, CRBP2 Rattus norvegicus EC- P06768 A29065 A92626 A94115 A32951 A25950 PS00214
Cellular Retinol-binding Protein type 2 RBP2, CRBP2 Sus scrofa EC- P50121 S45378 S45379 PS00214


GENE DATA

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Gene Subtype Locus Species Genbank Unigene Medline
Cellular Retinol-binding Protein
RBP1, CRBP1 Bos taurus S65585
93385352
Cellular Retinol-binding Protein
RBP1, CRBP1 Equus caballus U21208

Cellular Retinol-binding Protein type 1 RBP1, CRBP1 Homo sapiens M11433 M36809 X07437 S45496 X07438 X00129 X02824 AW18459 G11142 NM_002899 J04213 L34219 J04213 L34219 HS.101850 88185326 84069802 86055755 91042593 85279409 93038636
Cellular Retinol-binding Protein type 2 RBP2, CRBP2 Homo sapiens U13831 M68867 X07437 X07438 NM_004164
91373396 88185326 95386663
Cellular Retinol-binding Protein type 1 RBP1, CRBP1 Mus musculus X60367 NM_011254 Mm2450 91293098
Cellular Retinol-binding Protein type 2 RBP2, CRBP2 Mus musculus X74153 X74154 NM_009034 Mm12825 94117502
Cellular Retinol-binding Protein
RBP1, CRBP1 Oryctolagus cuniculus S45958
93011736
Cellular Retinol-binding Protein type 1 RBP1, CRBP1 Rattus norvegicus S45496 M16459 M19257 L02427 K03046 K03045 M10934 J02731 NM_012733 Rn.902 93038636 87204107 86008182 85207643 87222311
Cellular Retinol-binding Protein type 2 RBP2, CRBP2 Rattus norvegicus M13949 M16400 M16401 M16402 J02660 AH002152 NM_012640
86287337
Cellular Retinol-binding Protein type 1 RBP1, CRBP1 Sus scrofa X77639 M68860 X77641
92131004
Cellular Retinol-binding Protein type 2 RBP2, CRBP2 Sus scrofa X77639 X77641


GENE LOCUS DATA

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Gene Subtype Locus Species Genome Database Mouse Genome Database OMIM Locus Link
Cellular Retinol-binding Protein type 1 RBP1, CRBP1 Homo sapiens 120340 119548
180260 5947
Cellular Retinol-binding Protein type 2 RBP2, CRBP2 Homo sapiens 119548
180280 5948
Cellular Retinol-binding Protein type 1 RBP1, CRBP1 Mus musculus
Rbp1
19659
Cellular Retinol-binding Protein type 2 RBP2, CRBP2 Mus musculus
Rbp2
19660
Cellular Retinol-binding Protein type 1 RBP1, CRBP1 Rattus norvegicus


25056
Cellular Retinol-binding Protein type 2 RBP2, CRBP2 Rattus norvegicus


24710


Interphotoreceptor Retinol-binding Protien (IRBP, RBP3)
Human Data
Source data from literature
on this protein can be obtained here.
Editor's Notes
Subunit Subunits Aminoacids Modifications

1 1230 AA

Mr / Weight Cofactors / Substrates

133 kDa 11-cis-Retinal
Retinoic acid
all-trans-Retinol

Exons Transcripts Regulatory Elements

4
Retinoic acid Responsive Element
AP2-sites

Inhibitory cis element
Enhancing cis element

CRX-element
RET-1/PCE1-element

Markers / RFLPs Primers Assignment

Bgl II, Sty I
10p11.2-q11.2


PROTEIN DATA

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Protein Subtype Locus Species EC-No. Swissprot PIR Prosite
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Bos taurus EC- P12661 A32205 B25735 A22535 A23312
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Cavia porcellus EC-
D24417
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Cricetus cricetus EC-
G24417
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Homo sapiens EC- P10745 A33812 A31987 A35454 JS0307 H24417 S06277 S11279
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Macaca fascicularis EC-
A25735 E24417
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Mus musculus EC- P49194

Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Oryctolagus cuniculus EC- P12664 C24417
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Ovis aries EC- P12663 A24417
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Rana spec. EC-
I24417
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Sus scrofa EC- P12662 B24417
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Xenopus laevis EC- Q081107


GENE DATA

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Gene Subtype Locus Species Genbank Unigene Medline
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Bos taurus M19390 M20748 J04441 M19686 M32733 M27870 M26119
89093097 87293907 86025569 90006770
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Carassius auratus X80802
96081489
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Danio rerio X85957

Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Drosophila melanogaster U15004
95108022
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Elephantulus rufescens U48584
96304325
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Equus caballus U21208 U48710
96304325
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Erinaceus europaeus AF025390

Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Felis catus Z11811

Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Gorilla gorilla AF003994 AF003995
91319587
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Homo sapiens AF003990 AF003991 U34355 J05253 J03912 M33875 J05469 M22453 X53044 M45751 M45753 J04637 M24356 J05463 J05469 G26839 M33875 J04637 J24356 J33866 M33865 U66065 G22280 M33864 M33866 AH002852 NM_002900 Hs.857 88321820 89008429 90154038 89255256 90006790 90256745 91319587 96036069 90384818
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Loxodonta africana U48711
96304325
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Mus musculus S67113 M32734 Z11813 M74527 U63146 AF126968
92068183 92308333
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Pan troglodytes AF003992 AF003993
91319587
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Pongo pygmaeus AF003996
91319587
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Rattus norvegicus X56159
91115968
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Rattus rattus X69523
93272869
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Saimiri boliviensis U18617
96111507
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Saimiri sciureus U18619
9611507
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Sus scrofa U48588
96304325
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Xenopus laevis X69469
93366942


GENE LOCUS DATA

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Gene Subtype Locus Species Genome Database Mouse Genome Database OMIM Locus Link
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Homo sapiens 697229 120341
180290 5949
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Mus musculus
Rbp3
19661
Interphotoreceptor Retinoid-binding Protein
RBP3, IRBP Rattus norvegicus


24711


Serum Retinol-binding Protein (SRBP, RBP4)
Human Data
Source data from literature
on this protein can be obtained here.
Editor's Notes
Subunit Subunits Aminoacids Modifications

1


Mr / Weight Cofactors / Substrates




Exons Transcripts Regulatory Elements





Markers / RFLPs Primers Assignment

Flanking:
D10S571
D10S185

10q24


PROTEIN DATA

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Protein Subtype Locus Species EC-No. Swissprot PIR Prosite


GENE DATA

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Gene Subtype Locus Species Genbank Unigene Medline


GENE LOCUS DATA

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Gene Subtype Locus Species Genome Database Mouse Genome Database OMIM Locus Link


Retinyl Ester Hydrolase
Human Data
Source data from literature
on this protein can be obtained here.
Editor's Notes
Subunit Subunits Aminoacids Modifications





Mr / Weight Cofactors / Substrates




Exons Transcripts Regulatory Elements





Markers / RFLPs Primers Assignment





PROTEIN DATA

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Protein Subtype Locus Species EC-No. Swissprot PIR Prosite


GENE DATA

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Gene Subtype Locus Species Genbank Unigene Medline


GENE LOCUS DATA

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Gene Subtype Locus Species Genome Database Mouse Genome Database OMIM Locus Link


Retinol Dehydrogenase
11-cis RDH (11cRDH, RDH5)
all-trans RDH (atRDH)
Human Data
Source data from literature
on this protein can be obtained here.
Editor's Notes
Subunit Subunits Aminoacids Modifications
  1. 11cRDH (RDH5)
  2. atRDH
1
  1. 318 AA


Mr / Weight Cofactors / Substrates
  1. 11cRDH (RDH5)
  2. atRDH
  1. 32 kDa
  1. 11-cis-Retinol
    11-cis-Retinal

Exons Transcripts Regulatory Elements
  1. 11cRDH (RDH5)
  2. atRDH
  1. 5
  1. 1348 bp
  2. 1.8 kb


Markers / RFLPs Primers Assignment
  1. 11cRDH (RDH5)
  2. atRDH


  1. 12q13-14
  2. 1p36.1


PROTEIN DATA

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Protein Subtype Locus Species EC-No. Swissprot PIR Prosite
Retinol Dehydrogenase RDH5 Homo sapiens EC 1.1.1.105 Q29979 A55429 I45845
Retinol Dehydrogenase type 1 RDH1 Homo sapiens EC 1.1.1.105 Q92781

Retinol Dehydrogenase
RDH Rattus norvegicus EC 1.1.1.105 P50169 P50170 P55006 A55884 I55462 S39763
Retinol Dehydrogenase
RDH Rattus norvegicus EC 1.1.1.105 Q29979 A55429 I45845


GENE DATA

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Gene Subtype Locus Species Genbank Unigene Medline
Retinol Dehydrogenase RDH5 Homo sapiens U43559 AF037062 NM_002905 U89717 Hs.172914
Retinol Dehydrogenase type 1 RDH1 Homo sapiens U43559
97038684
Retinol Dehydrogenase type5 Rdh5 Mus musculus X97752 AF013288 AF033195 AF033196 Mm.7563
Retinol Dehydrogenase
RDH Rattus norvegicus U33500 U33501 U18762 S75875
96194805
Retinol Dehydrogenase
RDH Rattus norvegicus X82262 L36533
95386398 95138097


GENE LOCUS DATA

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Gene Subtype Locus Species Genome Database Mouse Genome Database OMIM Locus Link
Retinol Dehydrogenase RDH5 Homo sapiens
Rdh5
5959
Retinol Dehydrogenase type 1 RDH1 Homo sapiens

601617
Retinol Dehydrogenase
Rdh1 Mus musculus


19680
Retinol Dehydrogenase type5 Rdh5 Mus musculus


1968
Retinol Dehydrogenase

Rattus norvegicus


29449


Lecithin Retinol Acyl Transferase
Human Data
Source data from literature
on this protein can be obtained here.
Editor's Notes
Subunit Subunits Aminoacids Modifications

1 230 AA

Mr / Weight Cofactors / Substrates

25.3 kDa / 26 kDa (SDS Page)

Exons Transcripts Regulatory Elements


2615 bp

Markers / RFLPs Primers Assignment





PROTEIN DATA

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Protein Subtype Locus Species EC-No. Swissprot PIR Prosite


GENE DATA

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Gene Subtype Locus Species Genbank Unigene Medline


GENE LOCUS DATA

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Gene Subtype Locus Species Genome Database Mouse Genome Database OMIM Locus Link


References
  1. Boatright,J.H., Borst,D.E., Lin,Z.Y., Si,J.S., Bhati,M., Patel,D., Bruno,J., and Nickerson,J.M. Functional Characterization of Cis Acting Regulatory Elements of the IRBP Gene Promotor Region. 1995; Invest.Ophthalmol.Vis.Sci. 36: S123
    Goto Top

  2. Chen,Y. and Noy,N. Equilibrium and kinetic studies in the interactions of Interphotoreceptor Retinoid-binding Protein (IRBP). 1994; Invest.Ophthalmol.Vis.Sci. 35: 2061
    Goto Top

  3. Colantuoni,V., Cortese,R., Nilsson,M., Lundvall,J., Bavik,C.O., Eriksson,U., Peterson,P.A., and Sundelin,J. Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein. 1985; Biochem.Biophys.Res.Comm. 130: 431-439.
    Goto Top

  4. Demmer,L.A., Birkenmeier,E.H., Sweetser,D.A., Levin,M.S., Zollman,S., Sparkes,R.S., Mohandas,T., Lusis,A.J., and Gordon,J.I. The cellular retinol binding protein II gene. Sequence analysis of the rat gene, chromosomal localization in mice and humans, and documentation of its close linkage to the cellular retinol binding protein gene. 1987; J.Biol.Chem. 262: 2458-2467.
    Goto Top

  5. Fei,Y., Matragoon,S., and Liou,G.I. Characterization of the interphotoreceptor retinoid binding protein (IRBP) gene promotor. 1995; Invest.Ophthalmol.Vis.Sci. 36: S123
    Goto Top

  6. Haeseleer,F., Huang,J., Buczylko,J., Possin,D.E., Lebioda,L., Sokal,I., Palczewski,K., and Saari,J.C. Characterization Of A Putative Photoreceptor All-Trans-Retinol Dehydrogenase (RDH). 1998; Invest.Ophthalmol.Vis.Sci. 39: S423
    Goto Top

  7. Liou,G.I., Ma,D.P., Yang,Y.W., Geng,L., Zhu,C., and Baehr,W. Human interstitial retinoid-binding protein. Gene structure and primary structure. 1989; J.Biol.Chem. 264: 8200-8206.
    Link to PubMed
    Goto Top

  8. McGee,T.L., Berson,E.L., and Dryja,T.P. Search for point mutations in the interstitial retinol-binding protein gene in patients with hereditary retinal degenerations. 1992; Invest.Ophthalmol.Vis.Sci. 33 (Suppl.): 1396
    Goto Top

  9. Nilsson,M.H., Spurr,N.K., Lundvall,J., Rask,L., and Peterson,P.A. Human cellular retinol-binding protein gene organization and chromosomal location. 1988; Eur.J.Biochem. 173: 35-44.
    Goto Top

  10. Rocchi,M., Covone,A., Romeo,G., Faraonio,R., and Colantuoni,V. Regional mapping of RBP4 to 10q23----q24 and RBP1 to 3q21----q22 in man. 1989; Somatic.Cell and.Molecular.Genetics. 15: 185-190.
    Goto Top

  11. Ruiz,A., Winston,A., Rando,R., and Bok,D. Molecular Cloning And Characterization Of Lecithin Retinol Acyltransferase (LRAT) In Human Retinal Pigment Epithelium. 1998; Invest.Ophthalmol.Vis.Sci. 39: S423
    Goto Top

  12. Seeliger,M.W., Biesalski,H.K., Wissinger,B., Gollnick,H., Gielen,S., Frank,J., Beck,S., and Zrenner,E. Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis. 1999; Invest.Ophthalmol.Vis.Sci. 40: 3-11.
    Link to PubMed
    Goto Top

  13. Simon,A., Lagercrantz,J., Bajalica Lagercrantz,S., and Eriksson,U. Primary structure of human 11-cis retinol dehydrogenase and organization and chromosomal localization of the corresponding gene. 1996; Genomics. 36: 424-430.
    Goto Top

  14. Yokoyama,T., Liou,G.I., Caldwell,R.B., and Overbeek,P.A. Photoreceptor-specific activity of the human interphotoreceptor retinoid-binding protein (IRBP) promoter in transgenic mice. 1992; Exp.Eye Res. 55: 225-233.
    Link to PubMed
    Goto Top


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This site is maintained and edited by
Dr. rer. medic. Markus Preising, Dipl.Biol.
Molecular Genetics Laboratory

Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics
University of Regensburg
Head: Prof. Dr. med. Birgit Lorenz