Databases Protein Database

Recent update from: 25.04.2005

Proteins Involved in Retinal Disorders	Proteins Not Involved in Retinal Disorders
Proteins of the Visual Cascade
Rhodopsin (RHO) Photopigments Blue Cone Pigment (BCP) Green Cone Pigment (GCP) Red Cone Pigment (RCP) Transducin Rod Transducin, a-subunit (GNAT1) Cone Transducin, a-subunit (GNAT2) cGMP Phosphodiesterase (PDE6) Rod, a-subunit (PDE6A) Rod, b-subunit (PDE6B) Cyclic Nucleotide-gated Cation Channel Rod, a-subunit (CNGA1) Cone, a-subunit (CNGA3) Cone, b-subunit (CNGB3)
Controlling and Supplying the Visual Cascade
L-type Calcium-Channel (CACNA1F) Rhodopsin Kinase (RHOK) Arrestin (SAG) Protein Kinase C (PRKC)	Phosducin (PDC) Protein Phosphatase 2a (PP2A) Retina-specific Phospholipases (PLA2) Recoverin (RCV1)
Recovery of cGMP and Cation Concentrations of the Dark State
Retinal Guanylate Cyclase Retinal Guanylate Cyclase, type 1 (RetGC1, GUC2D) Retinal Guanylate Cyclase, type 2 (RetGC2) Guanylate Cyclase activating Protein Guanylate Cyclase activating Protein 1 (GCAP1, GUCA1A) Guanylate Cyclase activating Protein 2 (GCAP2, GUCA1B)	Na/Ca/K-Exchanger (NCKX)
Recovery and Supply of the Chromophore
ATP-binding Cassette Transporter (ABCR, ABCA4) Cellular Retinaldehyde-binding Protein (CRAlBP, RLBP1) Retinol Dehydrogenases 11-cis Retinol Dehydrogenase (RDH5) all-trans/11-cis Retinol Dehydrogenase (RDH12) RPE65 Lecithin Retinol Acyl Transferase (LRAT) Serum Retinol-binding Protein (SRBP, RBP4) RPE-retinal G-protein-coupled Receptor (RGR)	Cellular Retinol-binding Protein (CRBP) Interphotoreceptor Retinoid-binding Protein (IRBP, RBP3) Retinol Ester Hydrolase (REH) all-trans Retinol Dehydrogenase (RDH10)
Cellular Trafficking
Retinitis pigmentosa GTPase-Regulator(RPGR) Retinitis pigmentosa GTPase-Regulator-interacting Protein (RPGRIP1) Rab Escort Protein (REP1) Myosin VIIa (MyoVIIa) Regulator of G-Protein Signalling 9 (RGS9) Regulator of G-Protein Signalling 9 anchor protein (R9AP) Small GTP-binding protein Rab27a Rab3A-interacting molecule (RIM1) Ocular Albinism 1 Gene (OA1) Chediak-Higashi Syndrome Protein 1 (CHS1) Hermansky-Pudlak-Syndrome Proteins pale ear (HPS1, ep ) Adaptor-3-Complex, b3A-subunit (ADTB3A) HPS3 light ear (HPS4, le) ruby eye (HPS5, ru) ruby eye2 (HPS6, ru2) Dysbindin (DTNBP1)	Small GTP-binding proteins (Rab Proteins) Rab GDP Dissociation Inhibitor (GDI) and Dissociation Inhibitor -like Protein GTPase-activating Protein (GAP)
Proteins of the Cytoskeleton
Cadherin 3(CDH3) Cadherin 23(CDH23) Protocadherin 15(PCDH15) Collagen 2, a-subunit 1 (COL2A1)
Proteins involved in Splicing
U4/U6-associated Splicing Factor (HPPRP3) RNA Processing Factor 31 (PRPF31) Precursor of mRNA Processing Protein 8 (PPRPC8)
Control by Modification of Proteins
Geranyl-Geranyl Transferases I (GGTaseI)	Prenyl Transferases (GGTaseII, FTase)
Maintaining the Structural Integrity of Retinal Cells and Tissues
Prominin (mouse)-like1 (PROML1) RDS/Peripherin (RDS) and Rod Outer Membrane Protein 1 (ROM-1) Tissue Inhibitor of Metalloproteases 3 (TIMP3)
Transcription Factors
Cone-Rod Dystrophy Gene (CRX) Crumbs Homologue 1 (CRB1) Neuroretina Leucine-Zipper (NRL) NR2E3, Photoreceptor Cell-specific Nuclear Receptor (PNR, NR2E3) Frizzled 4 (FZD4)
Growth Factors
Norrin (NDG) X-linked Retinoschisis Gene (RS1)	Pigment Epithelium Differentiation Factor (PEDF)
Proteins of Unknown Function Underlying Retinal Disorders
Bestrophin (VMD2) Tubby-like Protein 1 (TULP1) EGF-containing fibrillin-like extracellular matrix protein 1 (EFEMP1) Elongation of Very Long Chain Fatty Acids-like Protein 4 (ELOVL4) MER Receptor Tyrosine Kinase (MERTK) Inosine Monophosphate Dehydrogenase 1 (IMPDH) Ceramide Kinase-like (CERKL) RP1 RP2 RP9 HRG4 Usher Syndrome-Genes Usher Syndrome Type 1c-Gene (USH1C) Usher Syndrome Type 2a-Gene (USH2A) Usher Syndrome Type 2c-Gene (VLGR1, MASS1) Usher Syndrome Type 3-Gene (CLARIN-1) Aryl Hydrocarbon Receptor-interacting Protein-like 1 (AIPL1) Multidrug Resistance-associated Protein 6 (ABCC6, MPR6) Nyctalopin (NYX) Bardet-Biedl Syndrome Genes Bardet-Biedl Syndrome 1 Gene (BBS2L2) Bardet-Biedl Syndrome 2 Gene (BBS2) Bardet-Biedl Syndrome 4 Gene (BBS4) Bardet-Biedl Syndrome 7 Gene (BBS2L1) McKusick-Kaufman Syndrome Gene (MKKS)
Melanogenesis
Tyrosinase (TYR) Tyrosinase-related Protein 1 (TRP 1) Membrane-associated Transport Protein (MATP) Pink Eye Dilution Gene (P) Melanocortin Receptor 1 (MC1R)

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Contact the editor	This site is maintained and edited by Dr. rer. medic. Markus Preising, Dipl.Biol. Molecular Genetics Laboratory Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics University of Regensburg Head: Prof. Dr. med. Birgit Lorenz