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Editor's Notes

from literature on

Lecithin Retinol Acyltransferase (LRAT)

Editor's Notes

Recent update from: 06.02.2000


LRAT,
Notes

  • In subfractions of RPE microsomes together with 11-cis-RDH-> branch point of esterification and oxidation in ER of RPE
  • No LRAT in PM
  • Esterpool in PM serves as precursor store of chromophore synthesis
Species: Bos taurus
See also:
Chromosomal localisation in man:

in mouse:
Gene Data

:

Exons:
Primers:
Protein Data
Amino acids:
Molecular weight on SDS-PAGE:

calculated:
Reference: (2)


LRAT,
Notes

  • Membrane bound
  • Expressed in fetal: RPE, liver, adult: RPE, prostate, testis, small intestine
  • Essential for biosynthesis of 11cRAl
  • Produces Ry for IMH
Species: Homo sapiens
See also:
Chromosomal localisation in man:

in mouse:
Gene Data
mRNA: 2615 bp
Exons:
Primers:
Protein Data
Amino acids: 230 AA
Molecular weight on SDS-PAGE: 26 kDa

calculated: 25.3 kDa
Reference: (1)


References:

1. Ruiz, A., Winston, A., Rando, R., and Bok, D. Molecular Cloning And Characterization Of Lecithin Retinol Acyltransferase (LRAT) In Human Retinal Pigment Epithelium. 1998; Invest.Ophthalmol.Vis.Sci. 39: S423
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2. Sierra, D.A., Tsin, A.T.C., Mata, N.L., and Villazana, E.T. Subcellular Distribution of 11-cis LRAT, 11-cis RD, and 11-cis REH in Bovine Pigment Epithelium. 1998; Invest.Ophthalmol.Vis.Sci. 39: S39
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Dr. rer. medic. Markus Preising, Dipl.Biol.
Molecular Genetics Laboratory
Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics
University of Regensburg
Head: Prof. Dr. med. Birgit Lorenz