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Scientific Newsletter

The Protein Pages

Cone-Rod Homeobox Gene
(CRX)

To see compiled data on further species click on the topics.
To see the reference for the human data click on the data

Editor's Notes from the Literature

Recent update from: 07.07.00


Description

CRX is a retina-specific transcription factor involved as major regulator of outer segment proteins in the expression of retinal genes (1).

GENE DATA

Exons: 3

Markers / RFLPs: D19S902
D19S412
D19S606

Transcripts: 4.5 kb

Regulatory elements:


Primers: complete + sequencing

Chromosome 19 with CRX locus
Assignment: 19q13.3 Involvement in Retinal Degenerations:

click here to see a compilation of

CLICK

several Mutations found to underlie

PROTEIN DATA

Subunits: 1 Amino acids: 299 AA
Modifications:


Mr/ Weight:

32 kDa / ?

Cofactors:

NRL

Motifs:


PROTEIN DATA

Click on entry to see database record online
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Protein Subtype Locus Species EC-No. Swissprot PIR Prosite
Cone-Rod Homeobox Gene
CRX Homo sapiens EC- O43186
PS00027 PS50071
Cone-Rod Homeobox Gene
Crx Mus musculus EC- O54751
PS00027 PS50071


GENE DATA

Click on entry to see database record online
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Gene Subtype Locus Species Genbank Unigene Medline
Cone-Rod Homeobox Gene
crx Bos taurus AF154123

Cone-Rod Homeobox Gene
CRX Homo sapiens AF024711 NM_000554 Hs.249186 98050929
Cone-Rod Homeobox Gene
Crx Mus musculus U77615 NM_007770 Mm.8008 98050928
Cone-Rod Homeobox Gene
crx Rattus norvegicus AB021129
99179974


GENE LOCUS DATA

Click on entry to see database record online
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Gene Subtype Locus Species Genome Database Mouse Genome Database OMIM Locus Link
Cone-Rod Homeobox Gene
CRX Homo sapiens 9836957
602225 1406
Cone-Rod Homeobox Gene
Crx Mus musculus
Crx
12951


References:
1. Freund,C.L., Gregory Evans,C.Y., Furukawa,T., Papaioannou,M., Looser,J., Ploder,L., Bellingham,J., Ng,D., Herbrick,J.A., Duncan,A., Scherer,S.W., Tsui,L.C., Loutradis Anagnostou,A., Jacobson,S.G., Cepko,C.L., Bhattacharya,S.S., and McInnes,R.R. Cone-rod dystrophy due to mutations in a novel photoreceptor- specific homeobox gene (CRX) essential for maintenance of the photoreceptor. 1997; Cell. 91: 543-553.
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2. Mitton,K.P., Swain,P.K., Chen,S., Apel,I.J., Zack,D.J., and Swaroop,A. Interaction Of Nrl With Crx And A Novel Zinc-Finger Protein As Detected By The Yeast Two-Hybrid Assay. 2000; Invest.Ophthalm.Vis.Sci. S389
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3. Sohocki,M.M., Malone,K.A., Sullivan,L.S., and Daiger,S.P. Identification and mapping of novel candidate genes for inherited retinal disorders. 1998; Am.J.Hum.Genet. 63: A386
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Contact the editor: irpamp@irpa.org
This site is maintained and edited by
Dr. rer. medic. Markus Preising, Dipl.Biol.
Molecular Genetics Laboratory
Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics
University of Regensburg
Head: Prof. Dr. med. Birgit Lorenz