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The Protein Pages

Cellular Retinaldehyde-binding Protein (CRAlBP, RLBP1)

To see compiled data on further species click on the topics.
To see the reference for the human data click on the data

Editor's Notes from the Literature

Recent update from: 09.01.2000


Description

Cellular Retinaldehyde-binding Protein (CRAlBP) is a watersoluble protein associated with the transport of 11-cis-RAl and 11-cis-Rol in the retina and RPE (10) , (1). The retina and pineal specific protein interacts with several retinoid processing enzymes including RDH thus supporting retinoid supply to retinal tissues (6), (7), (4) (3)

GENE DATA

Exons: 8

Markers / RFLPs:

D15S116
D15S152
D15S154
D15S1046

Transcripts:

Regulatory elements:

PCE1 element at -243 to +80
No TATA-box
SP1, AP2, NF, GT, STDR, reversed GC-box

Primers: Exons 2 -8

Chromosomes with CRAlBP locus
Assignment: 15q26 Involvement in Retinal Degenerations:

click here to see a compilation of

CLICK

several Mutations found to underlie

ARRP

PROTEIN DATA

Subunits: 1 Amino acids: 316 AA
Modifications: Mr/ Weight: 36378 / 36 kDa
Cofactors:

predominantly RAl,
11-cis-RAl saturated in mouse



PROTEIN DATA

Click on entry to see database record online
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Protein Subtype Locus Species EC-No. Swissprot PIR Prosite
Cellular Retinaldehyde-binding Protein
RLBP1, CRALBP Bos taurus EC- P10123 A31955 A30052
Cellular Retinaldehyde-binding Protein
RLBP1, CRALBP Homo sapiens EC- P12271 A49185 A49185


GENE DATA

Click on entry to see database record online
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Gene Subtype Locus Species Genbank Unigene Medline
Cellular Retinoic Acid-binding Protein type I CRABP1 Bos taurus M36808
X07436
M17253
BR>HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=91042593&dopt=Abstract">91042593
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=88185327&dopt=Abstract">88185327
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=87289661&dopt=Abstract">87289661
Cellular Retinoic Acid-binding Protein type I CRABP1 Gallus gallus X53701
Y12243
Y12244

HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=92155091&dopt=Abstract">92155091
Cellular Retinoic Acid-binding Protein type II CRABP2 Gallus gallus

Cellular Retinoic Acid-binding Protein type I RBP5, CRABP1 Homo sapiens S74445
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=92104256&dopt=Abstract">92104256
Cellular Retinoic Acid-binding Protein type II CRABP2 Homo sapiens M97815
M68867
M97814

HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=94350990&dopt=Abstract">94350990
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=93094236&dopt=Abstract">93094236
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=91373396&dopt=Abstract">91373396
Cellular Retinoic Acid-binding Protein type I CRABP1 Mus musculus S63446
X51715
X51716
X51717
X15789
X15481
M31552
M58013
M58014
M58015
X51827

HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=92037189&dopt=Abstract">92037189
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=91025549&dopt=Abstract">91025549
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=89339035&dopt=Abstract">89339035
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=89168179&dopt=Abstract">89168179
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=89313787&dopt=Abstract">89313787
Cellular Retinoic Acid-binding Protein type II CRABP2 Mus musculus M35523
M87538
M87539
M84142
M84143
L01528

HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=92218442&dopt=Abstract">92218442
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=93008245&dopt=Abstract">93008245
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=90349589&dopt=Abstract">90349589
Cellular Retinoic Acid-binding Protein type I CRABP1 Rattus norvegicus

Cellular Retinoic Acid-binding Protein type II CRABP2 Rattus norvegicus U23407
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=95269720&dopt=Abstract">95269720
Cellular Retinoic Acid-binding Protein
xCRABP Xenopus laevis S74933 Return to page head
Gene Subtype Locus Species Genome Database Mouse Genome Database OMIM Locus Link
Cellular Retinaldehyde-binding Protein
RLBP1, CRALBP Homo sapiens 127341
180090 6017
Cellular Retinaldehyde-binding Protein
Rlbp1, Cralbp Mus musculus


19771

References:
1. Bunt Milam,A.H. and Saari,J.C. Immunocytochemical localization of two retinoid-binding proteins in vertebrate retina. 1983; J.Cell Biol. 97: 703-712.
Goto Top Link to PudMed
2. Chen,Y., Goldflam,S., Johnson,C., West,K., and Crabb,J.W. The CRAlBP Retinoid Binding Domain. 1993; Invest.Ophthalmol.Vis.Sci. 34: 1198-1198.
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3. Crabb,J.W., Carlson,A., Chen,Y., Goldflam,S., Intres,R., West,K.A., Hulmes,J.D., Kapron,J.T., Luck,L.A., Horwitz,J., and Bok,D. Structural and functional characterization of recombinant human cellular retinaldehyde-binding protein. 1998; Protein Sci. 7: 746-757.
Goto Top Link to PudMed
4. Crabb,J.W., Gaur,V.P., Garwin,G.G., Marx,S.V., Chapline,C., Johnson,C.M., and Saari,J.C. Topological and epitope mapping of the cellular retinaldehyde- binding protein from retina. 1991; J.Biol.Chem. 266: 16674-16683.
Goto Top Link to PudMed
5. Crabb,J.W., Goldflam,S., Harris,S.E., and Saari,J.C. Cloning of the cDNAs encoding the cellular retinaldehyde-binding protein from bovine and human retina and comparison of the protein structures. 1988; J.Biol.Chem. 263: 18688-18692.
Goto Top Link to PudMed
6. Crabb,J.W., Johnson,C.M., Carr,S.A., Armes,L.G., and Saari,J.C. The complete primary structure of the cellular retinaldehyde- binding protein from bovine retina. 1988; J.Biol.Chem. 263: 18678-18687.
Goto Top Link to PudMed
7. Jones,S.E., Jomary,C., and Neal,M.J. Expression of TIMP3 mRNA is elevated in retinas affected by simplex retinitis pigmentosa. 1994; FEBS Lett. 352: 171-174.
Goto Top Link to PudMed
8. Kennedy,B.N., Goldman,S., Chang,M.A., Hackett,S., Campochiaro,P., Davis,A., Zack,D.J., and Crabb,J.W. Promotor Analysis of the Human CRALBP Gene. 1995; Invest.Ophthalmol.Vis.Sci. 36: S124
Goto Top
9. Maw,M.A., Kennedy,B., Knight,A., Bridges,R., Roth,K.E., Mani,E.J., Mukkadan,J.K., Nancarrow,D., Crabb,J.W., and Denton,M.J. Mutation of the gene encoding cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa. 1997; Nat.Genet. 17: 198-200.
Goto Top Link to PudMed
10. Saari,J.C., Bredberg,L., and Garwin,G.G. Identification of the endogenous retinoids associated with three cellular retinoid-binding proteins from bovine retina and retinal pigment epithelium. 1982; J.Biol.Chem. 257: 13329-13333.
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11. Saari,J.C., Huang,J., Champer,R.J., Kennedy,B.N., Goldflam,S., and Crabb,J.W. Cloning of the mouse gene encoding cellular retinaldehyde binding protein (CRALBP). 1995; Invest.Ophthalmol.Vis.Sci. 36: S125
Goto Top
12. Sparkes,R.S., Heinzmann,C., Goldflam,S., Kojis,T., Saari,J.C., Mohandas,T., Klisak,I., Bateman,J.B., and Crabb,J.W. Assignment of the Gene (RLBP1) for Cellular Retinaldehyde- Binding Protein (CRALBP) to Human Chromosome-15q26 and Mouse Chromosome-7. 1992; Genomics. 12: 58-62.
Goto Top Link to PudMed
13. Yuan,C.C., Crabb,J.W., Fishman,G.A., Jacobson,S.G., and Musarella,M.A. Exclusion of Cellular Retinaldehyde-binding Protein (CRAlBP) as a candidate gene for Stargardt's disease. 1994; Invest.Ophthalmol.Vis.Sci. 35: 1788-1788.
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This site is maintained and edited by
Dr. rer. medic. Markus Preising, Dipl.Biol.
Molecular Genetics Laboratory
Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics
University of Regensburg
Head: Prof. Dr. med. Birgit Lorenz