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The Protein Pages

Aryl Hydrocarbon Receptor-interacting
Protein-like 1 (AIPL1)

To see compiled data on further species click on the topics.
To see the reference for the human data click on the data

Editor's Notes from the Literature

Recent update from: 13.03.2003


Description

AIPL1 is a protein of yet unknown function. The protein contains TRP motifs. These indicate a function in nuclear transport or chaperone activity in protein folding.

GENE DATA

Exons: 6

Markers / RFLPs: D17S796
D17S1881
D17S1353

Transcripts:

Regulatory elements:

CRX

Primers:

Chromosomes with AIPL1 locus
Assignment: 17p13.1 Involvement in Retinal Degenerations:

click here to see a compilation of

CLICK

several Mutations found to underlie

LCA4

PROTEIN DATA

Subunits: 1 Amino acids: 384 AA
Modifications:

Mr/ Weight:

43865 Da /

Cofactors:



PROTEIN DATA

Click on entry to see database record online
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Subtype Locus Species EC-No. Swissprot TrEMBL Prosite

aipl1 Bos taurus

Q95MP1

AIPL1 Homo sapiens
Q9NZN9


aipl1 Macaca mulatta

Q95MP0

Aipl1 Mus musculus

Q924K1

aipl1 Pan paniscus

Q95MN9

aipl1 Papio cynocephalus

Q95MN8

aipl1 Rattus norvegicus
Q9JLG9


aipl1 Saimiri boliviensis

Q95MN7


GENE DATA

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Subtype Locus Species Genbank Unigene OMIM

aipl1 Bos taurus AF296410 NM_174234 Bt.8861

AIPL1 Homo sapiens AF180472 AF148864 AK023970 NT_010823 NM_014336 Hs.279887 604392

aipl1 Macaca mulatta AF296411


Aipl1 Mus musculus AF151392 AF296412 NM_053245 Mm.95707

aipl1 Pan paniscus AF296413


aipl1 Papio cynocephalus AF296414


aipl1 Rattus norvegicus AF180340 NM_021590 Rn.39120

aipl1 Saimiri boliviensis AF296415


aipl1 Saimiri sciureus AF180341


GENE LOCUS DATA

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Subtype Locus Species Genome Database Mouse Genome Database Locus Link

aipl1 Bos taurus

281609

AIPL1 Homo sapiens aipl1
23746

Aipl1 Mus musculus
Aipl1 114230

aipl1 Rattus norvegicus

59110


References:
  1. Akey,D.T., Zhu,X., Dyer,M., Li,A., Sorensen,A., Blackshaw,S., Fukuda-Kamitani,T., Daiger,S.P., Craft,C.M., Kamitani,T., and Sohocki,M.M. The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1. 2002; Hum.Mol.Genet. 11: 2723-2733.
    Link to PubMed
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  2. Sohocki,M.M., Bowne,S.J., Sullivan,L.S., Blackshaw,S., Cepko,C.L., Payne,A.M., Bhattacharya,S.S., Khaliq,S., Qasim Mehdi,S., Birch,D.G., Harrison,W.R., Elder,F.F., Heckenlively,J.R., and Daiger,S.P. Mutations in a new photoreceptor-pineal gene on 17p cause Leber congenital amaurosis. 2000; Nat.Genet. 24: 79-83.
    Link to PubMed
    Goto Top


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Contact the editor
This site is maintained and edited by
Dr. rer. medic. Markus Preising, Dipl.Biol.
Molecular Genetics Laboratory
Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics
University of Regensburg
Head: Prof. Dr. med. Birgit Lorenz